Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

Natural Evolution of Broadly Neutralizing Antibodies

Wu et al. couple next-generation sequencing with structural analysis to illuminate the key processes that enable the natural evolution and selection of broadly neutralizing antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies to accelerate the induction of protective antibodies.

Crossreactive Autoantibodies Directed against Cutaneous and Joint Antigens Are Present in Psoriatic Arthritis

BACKGROUND Psoriatic arthritis (PsA) is a chronic inflammatory disease of unknown origin, characterized by erosions and new bone formation. Diagnosis of PsA is mainly clinical and there are no biomarkers available. Moreover in PsA autoantibodies have not been described so far. Indeed an autoimmune origin has been suggested but never proven. Aim of the study was to investigate the possible prese...

SnapShot: Broadly Neutralizing Antibodies

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Blocking Chemokine Receptors

I n our first review on chemokines (1), we suggested that blockade of the IL-8 receptor or inhibition of IL-8 gene expression could be a new principle for designing antiin-flammatory agents. The unexpected growth of the chemo-kine family and consequent redundancy of the system eventually made it clear that acting at the level of chemo-kine gene expression was rather hopeless, but the idea of in...

Requirement of a Blocking Step in Affinity Purification of Polyclonal Antibodies